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Repatha® (evolocumab injection) is indicated:

  • as an adjunct to diet and standard of care therapy (including moderate- to high-intensity statin therapy alone or in combination with other lipid-lowering therapy) to reduce the risk of myocardial infarction, stroke and coronary revascularization in adult patients with atherosclerotic cardiovascular disease (ASCVD) by further lowering low-density lipoprotein cholesterol (LDL-C) levels
  • for the reduction of elevated LDL-C in adult patients with primary hyperlipidemia (including heterozygous familial hypercholesterolemia [HeFH] and ASCVD): as an adjunct to diet and statin therapy, with or without other lipid-lowering therapies, in patients who require additional lowering of LDL-C; or as an adjunct to diet, alone or in combination with non-statin lipid-lowering therapies, in patients for whom a statin is contraindicated
  • as an adjunct to diet and other LDL-C-lowering therapies (e.g., statins, ezetimibe, LDL apheresis) in adult patients with homozygous familial hypercholesterolemia (HoFH) who require additional lowering of LDL-C

Consult the Product Monograph at www.amgen.ca/Repatha_PM.pdf or here for important information about:

  • Contraindications in patients with hypersensitivity to Repatha®, any ingredient in the formulation or component of the container; refer to contraindications for any concomitant lipid-lowering medications
  • Warnings and precautions regarding any concomitant lipid-lowering medications; hypersensitivity or serious allergic reactions; no studies in pregnant or nursing women; no information on presence in human milk, effects on milk production, effects on or risk to breastfed infants; discontinuation in pregnancy; severe renal impairment; severe hepatic impairment; latex-sensitive patients and SureClick ® autoinjector needle cap; uncertain effects in patients with/at risk of hepatitis C virus infection
  • Conditions of clinical use, adverse reactions, drug interactions and dosing

The Product Monograph is also available by calling Amgen Medical Information at 1-866-502-6436.

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