Repatha® is available in clinically equivalent 140 mg Q2W and 420 mg QM fixed-dose dosage forms1

SureClick® autoinjector

Q2W dose: SureClick®️ autoinjector

Self-administered single-use, prefilled SureClick® autoinjector (about 15 sec)

  • Hidden 27-gauge needle
  • Consider for patients who are comfortable self-injecting with a hand-held device
Watch Sureclick®️ Injection Video
Automated mini-doser

QM dose: Automated mini-doser

Self-administered single monthly injection (12 injections/year) with automated mini-doser (about 5 min)

  • Hidden 29-gauge needle
  • Moderate physical activities can be performed during the injection process, such as walking, reaching, and bending
Watch AMD Injection Video

Recommended dosing for Repatha®1

Prevention of cardiovascular events and primary hyperlipidemia in adult patients (including HeFH and ASCVD)

The recommended dose for Repatha® is either 140 mg every two weeks or 420 mg once monthly; both doses are clinically equivalent. When switching dosage regimens, administer the first dose of the new regimen on the next scheduled date of the prior regimen.

  • One prefilled autoinjector delivers the 140 mg every two-weeks dose
  • One single-use automated mini-doser with 3.5 mL prefilled cartridge delivers the 420 mg once-monthly dose
  • Alternatively, three prefilled autoinjectors administered consecutively within 30 minutes delivers the 420 mg once-monthly dose

Homozygous familial hypercholesterolemia

The initial recommended dose is 420 mg once monthly. After 12 weeks of treatment, dose frequency can be up-titrated to 420 mg once every two weeks if a clinically meaningful response is not achieved. Patients on apheresis may initiate treatment with 420 mg every two weeks to correspond with their apheresis schedule.

  • One automated mini-doser with prefilled cartridge delivers the 420 mg once monthly dose
  • Alternatively, three prefilled autoinjectors administered consecutively within 30 minutes deliver the 420 mg once monthly or 420 mg every two-weeks dose

Please see the Product Monograph for complete dosing and drug interaction information.

Repatha® can be stored at room temperature for up to 30 days1

  • As standard practice, Repatha® should be stored in the refrigerator (2 to 8 °C) in the original carton
  • If removed from the refrigerator, Repatha® should be kept at controlled room temperature up to 25 °C in the original carton and must be used within 30 days
  • Protect from direct light and temperatures above 25 °C
  • Do not freeze. Do not shake.

Please see the Product Monograph for complete dosing and drug interaction information.

Download Patient Self-Injection Video Card Download Product Monograph

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